The Triglyceride-glucose (TyG) Index in the Association of Non-alcoholic Fatty Liver Disease, Obesity and Insulin Resistance

Service de Physiologie Clinique et Explorations Fonctionnelles Métaboliques et Nutrition du CHU de Batna, Centre Hospitalier Universitaire Benflis Touhami de Batna. Allées Mohamed Boudiaf Batna, Algérie

*Corresponding Author: Mohamed Ridha GUEDJATI, Service de Physiologie Clinique et Explorations Fonctionnelles Métaboliques et Nutrition du CHU de Batna, Algérie; Email: [email protected]

Received Date: February 26, 2024

Publication Date: March 20, 2024

Citation: GUEDJATI MR, et al. (2024). The Triglyceride-glucose (TyG) Index in the Association of Non-alcoholic Fatty Liver Disease, Obesity and Insulin Resistance. Diab Res. 1(1):1.

Copyright: GUEDJATI MR, et al. © (2024). 

ABSTRACT

Aims: Non-alcoholic fatty liver disease is strongly linked to obesity and insulin resistance. The triglyceride-glucose index (TyG index) has been proposed as a reliable biomarker of insulin resistance. Our aims is to study the contribution of the TyG index as a marker in the association of non-alcoholic fatty liver disease, obesity and insulin resistance. Material and method: This was a cross-sectional study of obese women (age>18years, BMI≥29.9Kg/m²). Non-alcoholic hepatitis steatosis was confirmed by abdominal ultrasound. The viral origin of the liver disease was eliminated by microbiological test. A lipid profile was performed. The TyG index was calculated according to the formula Ln[fasting triglycerides(mg/dL)×fasting glucose(mg/dL)/2. The relations between TyG index body composition and lipid profile was measured. Results: 42 obese women participated in our work. Age=50.80±10.33 years. BMI=40.80±5.09 Kg/m2; weight=98.1±15.99 Kg. Fasting blood sugar was 1.18±0.34 g/L. Triglycerides were 1.37±0.47 g/L. Our study demonstrated that 83% (n= 35) have, in addition to non-alcoholic fatty liver disease, a high TyG index (4.75+/-0.25) in favour of insulin resistance. The TyG index is strongly linked to fasting glucose (rs=0.83) and fasting triglycerides (rs=0.78). A statistically significant link was found between the TyG index and age (τ = 0.21, p=0.04), the TyG index and total cholesterol (τ = 0.33, p=0.001). Conclusions: The TyG index is a topical biomarker. This clue is practical. It appears to have a place in the association, obesity, non-alcoholic fatty liver disease and insulin resistance.

Keywords: TyG index, insulin resistance, obesity, non-alcoholic fatty liver disease